In 2014, Lowe wrote a second book titled Love Life, which was released in April that year.
He uses stories and observations from his life in a poignant and humorous series of true tales about men and women, art and commerce, fathers and sons, addiction and recovery, and sex and love.
In 2006 he filmed The Perfect Day for TNT, in which he took a pay cut to film in New Orleans in order to help the hurricane-ravaged area.
That same year, Lowe filmed Stir of Echoes: The Homecoming, the sequel to the 1999 Kevin Bacon thriller Stir of Echoes.
He came to prominence as a teen idol in the 1980s, appearing in teen and young adult film roles in The Outsiders (1983), Oxford Blues (1984), St. Lowe appeared as Robert Mc Callister on the ABC television drama Brothers & Sisters (2006–2010), followed by a four-year run as Chris Traeger on the NBC sitcom Parks and Recreation (2010–14), for which he was critically acclaimed. Ethan Willis on the CBS medical drama Code Black (2015–) and appears with his two sons, Matthew and John Owen, in the A&E reality series The Lowe Files (2017–).
Thereafter, his film career decreased and he ventured into television, making his breakthrough as Sam Seaborn on the NBC political drama The West Wing (1999–2003), for which he received a Primetime Emmy Award nomination and two Golden Globe Award nominations.
In 2004 Lowe starred in the TNT remake of the Stephen King miniseries Salem's Lot which was the highest rated cable program of that summer and the highest ratings TNT original programming had at the time.
In 2005 Lowe starred in the miniseries Beach Girls on the Lifetime network, based on the Luanne Rice novel of the same name.
He also appeared on The Tonight Show with Conan O'Brien.Eventually, Lowe left the series, not long before Sorkin and director/executive producer Thomas Schlamme unceremoniously quit over a dispute with NBC.During the final season of The West Wing, Lowe returned to his role of Sam Seaborn, appearing in two of the final four episodes.Soon after ABC announced an early Season 2 renewal for Brother & Sisters in March 2007, Lowe announced he would be returning for the show's second season.He continued to appear in the series until the end of the 2009–10 season.In addition to his 2001 Emmy nomination for The West Wing, He is of German, English, Irish, Scottish, and Welsh ancestry. , Lowe found out that one of his ancestors, Christopher East, was a Hessian soldier.His ancestor was fighting under the command of Colonel Johann Gottlieb Rall and was captured at the American victory at Trenton, New Jersey, on the morning of December 26, 1776.Despite his two cancelled TV series and flops like View From the Top and the made-for-TV movie Perfect Strangers during his post–West Wing run, Lowe found success in the TV miniseries genre.The year 2004 marked his return to this genre; he had appeared in 1994's The Stand, based on Stephen King's book of the same name.As an American POW, his ancestor was given a choice, and took the option to stay in the United States.One of Lowe's earliest roles came in the 1983 TV film Thursday's Child, for which he received his first Golden Globe Award nomination for Best Supporting Actor in a Series, Miniseries, or Television Film.